Heart Failure PhysioLab

20/09/2026

𝐀𝐈-𝐃𝐞𝐫𝐢𝐯𝐞𝐝 𝐒𝐜𝐨𝐫𝐞 𝐭𝐨 𝐏𝐫𝐞𝐝𝐢𝐜𝐭 𝐄𝐟𝐟𝐨𝐫𝐭 𝐈𝐧𝐭𝐨𝐥𝐞𝐫𝐚𝐧𝐜𝐞 𝐚𝐧𝐝 𝐀𝐝𝐯𝐞𝐫𝐬𝐞 𝐎𝐮𝐭𝐜𝐨𝐦𝐞𝐬 𝐀𝐜𝐫𝐨𝐬𝐬 𝐭𝐡𝐞 𝐇𝐞𝐚𝐫𝐭 𝐅𝐚𝐢𝐥𝐮𝐫𝐞 𝐒𝐩𝐞𝐜𝐭𝐫𝐮𝐦

𝐽𝑜𝑢𝑟𝑛𝑎𝑙 𝑜𝑓 𝐶𝑎𝑟𝑑𝑖𝑎𝑐 𝐹𝑎𝑖𝑙𝑢𝑟𝑒 - 𝐻𝑒𝑎𝑟𝑡 𝐹𝑎𝑖𝑙𝑢𝑟𝑒 𝑆𝑜𝑐𝑖𝑒𝑡𝑦 𝑜𝑓 𝐴𝑚𝑒𝑟𝑖𝑐𝑎


Università di Pisa Unità Valorizzazione Ricerca Unipi AOUP Azienda Ospedaliero Universitaria Pisana AOUP

🩺 @, S Moura Ferreira, G Georgiopoulos, G Mastoras, N De Biase, .difiore, Clara Macheda, G Savarese, S Taddei, J Verwerft, S Masi, Nicola Riccardo Pugliese

02/09/2026

𝐃𝐢𝐬𝐭𝐢𝐧𝐜𝐭 𝐄𝐱𝐞𝐫𝐜𝐢𝐬𝐞 𝐑𝐞𝐬𝐩𝐨𝐧𝐬𝐞 𝐏𝐚𝐭𝐭𝐞𝐫𝐧𝐬 𝐢𝐧 𝐏𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐖𝐢𝐭𝐡 𝐇𝐞𝐚𝐫𝐭 𝐅𝐚𝐢𝐥𝐮𝐫𝐞 𝐖𝐢𝐭𝐡 𝐏𝐫𝐞𝐬𝐞𝐫𝐯𝐞𝐝 𝐄𝐣𝐞𝐜𝐭𝐢𝐨𝐧 𝐅𝐫𝐚𝐜𝐭𝐢𝐨𝐧

💡Our last work on American Heart Association
Università di Pisa AOUP Azienda Ospedaliero Universitaria Pisana AOUP

🩺 Stephanie De Schutter, MD, .r.pugliese, MD, PhD, Laura M. G. Meems, MD, PhD, Sara Moura‐Ferreira, MD, Nicolò De Biase, MD, Lavinia Del Punta, MD, Stefano Masi, MD, PhD, Jan Stassen, MD, PhD, Lieven Herbots, MD, PhD, Guido Claessen, MD, PhD, Caroline M. Van de Heyning, MD, PhD, Jan Verwerft, MD, PhD, Andreas B. Gevaert, MD, PhD.

🔗https://doi.org/10.1161/JAHA.126.050524

01/09/2026

𝐀𝐈-𝐝𝐞𝐫𝐢𝐯𝐞𝐝 𝐬𝐜𝐨𝐫𝐞 𝐭𝐨 𝐩𝐫𝐞𝐝𝐢𝐜𝐭 𝐞𝐟𝐟𝐨𝐫𝐭 𝐢𝐧𝐭𝐨𝐥𝐞𝐫𝐚𝐧𝐜𝐞 𝐚𝐧𝐝 𝐚𝐝𝐯𝐞𝐫𝐬𝐞 𝐨𝐮𝐭𝐜𝐨𝐦𝐞 𝐚𝐜𝐫𝐨𝐬𝐬 𝐭𝐡𝐞 𝐡𝐞𝐚𝐫𝐭 𝐟𝐚𝐢𝐥𝐮𝐫𝐞 𝐬𝐩𝐞𝐜𝐭𝐫𝐮𝐦

💡Our last work on European Society of Cardiology
di Pisa AOUP Azienda Ospedaliero Universitaria Pisana AOUP

🩺 L Del Punta , S Moura Ferreira, G Georgiopoulos, G Mastoras, N De Biase, .difiore , Clara Macheda , G Savarese, S Taddei, J Verwerft, S Masi, .r.pugliese

🔗 https://doi.org/10.1093/ejhf/xuag193.735

09/03/2026

𝐇𝐞𝐦𝐨𝐝𝐲𝐧𝐚𝐦𝐢𝐜 𝐚𝐧𝐝 𝐌𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐜-𝐈𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐏𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐢𝐧𝐠 𝐀𝐜𝐫𝐨𝐬𝐬 𝐭𝐡𝐞 𝐂𝐚𝐫𝐝𝐢𝐚𝐜 𝐈𝐧𝐝𝐞𝐱 𝐒𝐩𝐞𝐜𝐭𝐫𝐮𝐦 𝐢𝐧 𝐌𝐨𝐝𝐞𝐫𝐚𝐭𝐞 𝐚𝐧𝐝 𝐒𝐞𝐯𝐞𝐫𝐞 𝐓𝐫𝐢𝐜𝐮𝐬𝐩𝐢𝐝 𝐑𝐞𝐠𝐮𝐫𝐠𝐢𝐭𝐚𝐭𝐢𝐨𝐧: 𝐏𝐫𝐨𝐠𝐧𝐨𝐬𝐭𝐢𝐜 𝐈𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬

💡Our last paper on American Heart Association
𝐶𝑖𝑟𝑐𝑢𝑙𝑎𝑡𝑖𝑜𝑛: 𝐶𝑎𝑟𝑑𝑖𝑜𝑣𝑎𝑠𝑐𝑢𝑙𝑎𝑟 𝐼𝑚𝑎𝑔𝑖𝑛𝑔

Università di Pisa Unità Valorizzazione Ricerca Unipi AOUP Azienda Ospedaliero Universitaria Pisana AOUP

🩺Authors: Matteo Mazzola, MD; Nicolò De Biase, MD; Cristina Giannini, MD, PhD; Alessandro Sticchi, MD, PhD; Lavinia Del Punta, MD; Luna Gargani, MD, PhD; Alessandro Mengozzi, MD, PhD; Agostino Virdis, MD, PhD; Silvia Armenia, BSc; Federica Cappelli, BSc; Emiliano Duranti, BSc; Stefano Taddei, MD, PhD; Rebecca Hahn, MD, PhD; David Messika-Zeitoun, MD, PhD; Stefano Masi, MD, PhD*; Marco De Carlo, MD, PhD*; Nicola Riccardo Pugliese, MD, PhD*.

🔗https://doi.org/10.1161/CIRCIMAGING.125.019444

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02/02/2026

𝐕𝐞𝐧𝐭𝐫𝐢𝐜𝐮𝐥𝐚𝐫-𝐀𝐫𝐭𝐞𝐫𝐢𝐚𝐥 𝐂𝐨𝐮𝐩𝐥𝐢𝐧𝐠 𝐃𝐞𝐫𝐢𝐯𝐞𝐝 𝐅𝐫𝐨𝐦 𝐏𝐫𝐨𝐱𝐢𝐦𝐚𝐥 𝐀𝐨𝐫𝐭𝐢𝐜 𝐒𝐭𝐢𝐟𝐟𝐧𝐞𝐬𝐬 𝐚𝐧𝐝 𝐀𝐞𝐫𝐨𝐛𝐢𝐜 𝐂𝐚𝐩𝐚𝐜𝐢𝐭𝐲 𝐀𝐜𝐫𝐨𝐬𝐬 𝐭𝐡𝐞 𝐇𝐞𝐚𝐫𝐭 𝐅𝐚𝐢𝐥𝐮𝐫𝐞 𝐒𝐩𝐞𝐜𝐭𝐫𝐮𝐦

💡Our last paper on European Society of Cardiology
𝐸𝑢𝑟𝑜𝑝𝑒𝑎𝑛 𝐻𝑒𝑎𝑟𝑡 𝐽𝑜𝑢𝑟𝑛𝑎𝑙. 𝐴𝑐𝑢𝑡𝑒 𝐶𝑎𝑟𝑑𝑖𝑜𝑣𝑎𝑠𝑐𝑢𝑙𝑎𝑟 𝐶𝑎𝑟𝑒

🩺Authors: Valerio Di Fiore, Lavinia Del Punta, Nicolò De Biase, Nicola Riccardo Pugliese

🔗 https://doi.org/10.1093/ehjacc/zuag014

Valerio Di Fiore, MD, Lavinia Del Punta, MD, Nicolò De Biase, MD, Nicola Riccardo Pugliese, MD, PhD; Ventricular-Arterial Coupling Derived From Proximal Ao

08/11/2025

𝐏𝐫𝐨𝐠𝐧𝐨𝐬𝐭𝐢𝐜 𝐕𝐚𝐥𝐮𝐞 𝐨𝐟 𝐄𝐱𝐞𝐫𝐜𝐢𝐬𝐞 𝐑𝐢𝐠𝐡𝐭 𝐕𝐞𝐧𝐭𝐫𝐢𝐜𝐮𝐥𝐚𝐫–𝐏𝐮𝐥𝐦𝐨𝐧𝐚𝐫𝐲 𝐀𝐫𝐭𝐞𝐫𝐢𝐚𝐥 𝐂𝐨𝐮𝐩𝐥𝐢𝐧𝐠 𝐢𝐧 𝐏𝐫𝐢𝐦𝐚𝐫𝐲 𝐌𝐢𝐭𝐫𝐚𝐥 𝐑𝐞𝐠𝐮𝐫𝐠𝐢𝐭𝐚𝐭𝐢𝐨𝐧

💡Our last paper on 𝐶𝑖𝑟𝑐𝑢𝑙𝑎𝑡𝑖𝑜𝑛 American Heart Association

Università di Pisa Unità Valorizzazione Ricerca Unipi AOUP Azienda Ospedaliero Universitaria Pisana AOUP

🩺Authors: Sara Moura-Ferreira; Nicola Riccardo Pugliese; Mauricio Milani; Stefano Taddei; Annemie Jacobs; Nicolò De Biase; Sebastiaan Dhont; Maarten Falter; Youri Bekhuis; Wouter L’Hoyes; Sarah Hoedemakers; Steven Droogmans; Bernard Cosyns; Ruta Jasaityte; Guido Claessen; Lavinia Del Punta; Lieven Herbots; Marco De Carlo; Matteo Mazzola; Philippe B. Bertrand; Giosuè Falcetta;
Philippe Debonnaire; Stefano Masi; Jan Verwerft.

🔗 https://doi.org/10.1161/CIRCULATIONAHA.125.073778

BACKGROUND: Managing clinically significant primary mitral regurgitation is challenging. Right ventricular–pulmonary arterial coupling, assessed with tricuspid annular plane systolic excursion (TAPSE) and systolic pulmonary artery pressure (sPAP) ratio, reflects right ventricular adaptability to a...

29/10/2025

𝐄𝐱𝐡𝐚𝐥𝐞𝐝 𝐛𝐫𝐞𝐚𝐭𝐡 𝐚𝐜𝐞𝐭𝐨𝐧𝐞: 𝐚 𝐧𝐨𝐧-𝐢𝐧𝐯𝐚𝐬𝐢𝐯𝐞 𝐦𝐚𝐫𝐤𝐞𝐫 𝐨𝐟 𝐝𝐢𝐬𝐞𝐚𝐬𝐞 𝐬𝐞𝐯𝐞𝐫𝐢𝐭𝐲 𝐚𝐜𝐫𝐨𝐬𝐬 𝐭𝐡𝐞 𝐬𝐩𝐞𝐜𝐭𝐫𝐮𝐦 𝐨𝐟 𝐡𝐞𝐚𝐫𝐭 𝐟𝐚𝐢𝐥𝐮𝐫𝐞

💡Our last paper on 𝐽𝑜𝑢𝑟𝑛𝑎𝑙 𝑜𝑓 𝐵𝑟𝑒𝑎𝑡ℎ 𝑅𝑒𝑠𝑒𝑎𝑟𝑐ℎ IOP Publishing

AOUP Azienda Ospedaliero Universitaria Pisana AOUP Unità Valorizzazione Ricerca Unipi Università di Pisa

🩺Authors: Nicolò De Biase, Silvia Ghimenti, Lavinia Del Punta, Denise Biagini, Alessio Lenzi, Fabio Di Francesco, Stefano Taddei, Pierpaolo Pellicori, Stefano Masi, Tommaso Lomonaco and Nicola Riccardo Pugliese

🔗

Exhaled breath acetone: a non-invasive marker of disease severity across the spectrum of heart failure, De Biase, Nicolò, Ghimenti, Silvia, Del Punta, Lavinia, Biagini, Denise, Lenzi, Alessio, Di Francesco, Fabio, Taddei, Stefano, Pellicori, Pierpaolo, Masi, Stefano, Lomonaco, Tommaso, Pugliese, Ni...

02/09/2025

𝐸𝑥𝑝𝑙𝑜𝑟𝑖𝑛𝑔 𝑐𝑖𝑟𝑐𝑢𝑙𝑎𝑡𝑖𝑛𝑔 𝑚𝑖𝑡𝑜𝑐ℎ𝑜𝑛𝑑𝑟𝑖𝑎𝑙 𝐷𝑁𝐴 𝑠𝑖𝑔𝑛𝑎𝑡𝑢𝑟𝑒 𝑎𝑐𝑟𝑜𝑠𝑠 𝑡ℎ𝑒 𝑐𝑎𝑟𝑑𝑖𝑜𝑣𝑎𝑠𝑐𝑢𝑙𝑎𝑟 𝑠𝑝𝑒𝑐𝑡𝑟𝑢𝑚

Kudos to our Nicola Riccardo Pugliese ! 🏆🥇🎉

𝗬𝗼𝘂𝗻𝗴 𝗜𝗻𝘃𝗲𝘀𝘁𝗶𝗴𝗮𝘁𝗼𝗿 𝗔𝘄𝗮𝗿𝗱 @ European Society of Cardiology

ESC Congress 2025
Madrid, 29 August – 1 September

09/07/2025

𝐀𝐝𝐯𝐚𝐧𝐜𝐢𝐧𝐠 𝐂𝐚𝐫𝐝𝐢𝐨𝐯𝐚𝐬𝐜𝐮𝐥𝐚𝐫 𝐑𝐢𝐬𝐤 𝐒𝐭𝐫𝐚𝐭𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐅𝐮𝐧𝐜𝐭𝐢𝐨𝐧𝐚𝐥 𝐀𝐬𝐬𝐞𝐬𝐬𝐦𝐞𝐧𝐭: 𝐀 𝐍𝐚𝐫𝐫𝐚𝐭𝐢𝐯𝐞 𝐑𝐞𝐯𝐢𝐞𝐰 𝐨𝐟 𝐂𝐏𝐄𝐓 𝐚𝐧𝐝 𝐄𝐒𝐄 𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬

💡Our last paper on Healthcare MDPI

AOUP Azienda Ospedaliero Universitaria Pisana AOUP
Università di Pisa
Unità Valorizzazione Ricerca Unipi
Fondazione Monasterio
Scuola Superiore Sant'Anna

🩺 Authors: Valerio Di Fiore , Lavinia Del Punta , Nicolò De Biase , Stefano Masi, Stefano Taddei, Javier Rosada, Michele Emdin, Claudio Passino, Iacopo Fabiani, and Nicola Riccardo Pugliese

🔗 https://www.mdpi.com/2227-9032/13/13/1627

Cardiopulmonary exercise testing combined with exercise stress Echocardiography (CPET-ESE) is an advanced diagnostic modality for evaluating cardiovascular disease and tailoring patient-specific treatment strategies. By integrating metabolic, ventilatory, and hemodynamic data with real-time imaging,...

23/05/2025

𝐑𝐞𝐟𝐢𝐧𝐢𝐧𝐠 𝐭𝐡𝐞 𝐥𝐢𝐧𝐤 𝐛𝐞𝐭𝐰𝐞𝐞𝐧 𝐨𝐛𝐞𝐬𝐢𝐭𝐲 𝐚𝐧𝐝 𝐡𝐞𝐚𝐫𝐭 𝐟𝐚𝐢𝐥𝐮𝐫𝐞: 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐟𝐫𝐨𝐦 𝐆𝐋𝐏-𝟏 𝐫𝐞𝐜𝐞𝐩𝐭𝐨𝐫 𝐚𝐠𝐨𝐧𝐢𝐬𝐭 𝐭𝐫𝐢𝐚𝐥𝐬 𝐚𝐧𝐝 𝐬𝐭𝐮𝐝𝐢𝐞𝐬 𝐚𝐝𝐨𝐩𝐭𝐢𝐧𝐠 𝐝𝐢𝐫𝐞𝐜𝐭 𝐚𝐝𝐢𝐩𝐨𝐬𝐢𝐭𝐲 𝐦𝐞𝐚𝐬𝐮𝐫𝐞𝐬

💡Our last paper on 𝐶𝑎𝑟𝑑𝑖𝑜𝑣𝑎𝑠𝑐𝑢𝑙𝑎𝑟 𝐷𝑖𝑎𝑏𝑒𝑡𝑜𝑙𝑜𝑔𝑦 BMC

AOUP Azienda Ospedaliero Universitaria Pisana AOUP Università di Pisa Unità Valorizzazione Ricerca Unipi

🩺Authors: Nicola Riccardo Pugliese, Francesco Paneni, Domenico Tricò, Alessandra Violet Bacca, Nicolò De Biase , Hermann Dalpiaz, Alessandro Mengozzi, Agostino Virdis, Lorenzo Ghiadoni, Stefano Taddei, Reinhold Kreutz, Konstantinos Tsioufis & Stefano Masi.

🔗https://cardiab.biomedcentral.com/articles/10.1186/s12933-025-02778-6

Overweight and obesity are major risk factors for heart failure (HF), contributing to its development through metabolic, neurohormonal, haemodynamic, and inflammatory alterations. While overweight/obesity increases the risk of developing HF, its impact on patient outcomes remains complex. The “obe...