07/07/2026
Adjunctive Psychosocial Interventions and Opioid Abstinence Among Patients Receiving Buprenorphine
A Randomized Clinical Trial
Michelle R. Lent, PhD1; Emily E. Hurstak, MD, MPH2; Kevin G. Lynch, PhD3 et al
JAMA Netw Open
Published Online: June 23, 2026
Key Points
Question What is the comparative effectiveness of 2 psychosocial treatments—cognitive-behavioral therapy (CBT) and peer recovery support (PRS)—on opioid abstinence when used as adjunctive therapy to office-based buprenorphine treatment in adults with opioid use disorder (OUD)?
Findings This randomized clinical trial of 340 adults with OUD taking buprenorphine found that neither PRS, CBT, nor a combination of these psychosocial interventions yielded differential effects on opioid abstinence.
Meaning These results suggest that adjunctive psychosocial interventions may not enhance buprenorphine treatment outcomes in the early stages of treatment.