06/09/2026
Whoooo! What a day! This post is a little late BUT letโs start the discussion of PEPTIDES ๐๐ผ๐๐ผ. Over the next few weeks I will begin discussing each individual peptide along with the benefits supporting each one. Letโs start with the most talked about peptide, GLP1, GIP, and Glucagon.
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A novel triple receptor agonist targeting glucagon-like peptide-1 (GLP-1), Glucose-Dependent Insulinotropic Polypeptide (GIP), and glucagon receptors.
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Has a unique molecular structure enables potent activation of GLP-1, GIP, and glucagon receptors, leading to significant weight reduction (up to 25%), improved glycemic control, and favorable metabolic outcomes.
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Phase I and II clinical trials support these findings, showing dose-dependent weight loss, reductions in Glycated Hemoglobin (HbA1c) levels, and improvements in liver steatosis and diabetic kidney disease. ๐ซถ๐ผ
โจ GLP:1 is an incretin hormone that is predominantly secreted from the intestinal tract, mainly as a response to meals. It acts by activating receptors that stimulates insulin release, lowers glucagon secretion, decreases food intake, and delays gastric emptying (GE). GLP-1 activation is also shown to reduce inflammation by reducing macrophage activity.
โจ GIP: Glucose Dependent Insulinotropic Polypeptide. Also excreted from intestinal K cells, GIP is a protein mostly postprandially secreted. When activated, an increase in intracellular calcium and arachidonic acid occurs. It also reduces appetite by having a negative impact on GE and by enabling insulin release from the pancreas, working with GLP-1. GIP effects regarding adipose tissue, optimizing insulin secretion and results in fat burning.
โจGlucagon: formed from a precursor pro-glucagon molecule of 180 amino acids, is a hormone that is mostly found in pancreatic ฮฑ-cells. Glucagon receptors result in lower glucose blood levels, and glucagon receptors are found in many tissues, with hepatocytes being the most common place. Glucagon promotes thermogenesis, promotes energy and rapid fat burning properties.
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