10/30/2026
Ozone Therapy: A potential tool in the treatment of Breast Cancer?
A 2024 literature review explores ozone therapy as a potential adjunct to conventional breast cancer care.
What have human clinical studies reported...
• Reducing chemotherapy-related side effects: In a study of 32 patients, ozone therapy administered after chemotherapy was associated with reduced treatment toxicity, improved quality of life, and improved immune and antioxidant parameters.
• Supporting surgical recovery: Among 151 patients undergoing breast reconstruction, those receiving ozone therapy showed improved tissue oxygenation and blood flow, faster lymphocyte recovery, and fewer early postoperative complications.
• Managing breast cancer-related lymphedema: A randomized clinical study involving 60 patients reported greater reductions in limb volume and thickness when ozone therapy was added to physical therapy.
• Reducing cancer-related fatigue: In a study of 15 patients, 11 (73%) experienced a significant reduction in fatigue following ozone therapy, without significant side effects reported in that small study.
• Supporting wound healing and symptom relief: A single-patient report described improvements in pain, symptoms, and tissue fibrosis associated with a persistent fistula in a previously irradiated area.
What is the proposed application...
Ozone therapy is being investigated as a complementary approach to help manage treatment-related side effects, improve tissue oxygenation and circulation, support recovery, and potentially influence immune responses. Laboratory research also suggests possible synergy with chemotherapy and radiation—but these anticancer effects have not been established in human clinical trials.
The important caveat…
These findings are preliminary. Larger, well-designed clinical trials are needed to establish its safety, efficacy, and optimal use in breast cancer treatment.
PMID: 38258533