09/10/2026
GLP-1, GIP, and glucagon — what’s actually the difference?
Semaglutide, tirzepatide, and retatrutide target different metabolic hormone pathways involved in appetite, glucose regulation, and energy balance.
Semaglutide → GLP-1
Tirzepatide → GLP-1 + GIP
Retatrutide → GLP-1 + GIP + Glucagon*
Understanding how these pathways differ can help make the science behind metabolic health easier to understand.
At Immunity Center, we believe education comes first. Treatment decisions should always be individualized and discussed with a qualified healthcare provider.
*Retatrutide is investigational and is not FDA-approved.