10/13/2026
The largest exercise trial ever run in metastatic breast cancer enrolled 357 patients.
74% of them had bone metastases.
Nine months of supervised aerobic, resistance, and balance training. What was the outcome?
Less fatigue. Better quality of life that was maintained at nine months. Better physical functioning, less pain, less shortness of breath, more lean muscle, more lower-body strength, better balance.
That's PREFERABLE-EFFECT, published in Nature Medicine in 2024.
I'm posting this because for decades, people with metastatic disease were excluded from exercise research. Not because anyone proved it was unsafe, but because studies were designed without them.
So if you've never been told whether movement is safe for you, you didn't miss anything.
⚠️ The trial excluded people with unstable bone metastases, so whether yours are stable requires your imaging and your oncologist.
I can't determine that. No trainer can. No post on the internet can.
If a bone's structural integrity is compromised and you load it, the consequence is a fracture, and I'm not willing to be the reason that happens to anyone.
So I urge you to take one sentence to your oncologist:
"Are my bone mets considered stable, and am I cleared for supervised resistance and aerobic exercise?"
Then find someone who knows what to do with the answer 🙋♀️
One more thing, because I'd rather say it than let it be assumed: this trial measured fatigue, quality of life, strength, and function.
It did not measure survival.
Exercise is not to be used as the sole treatment for your cancer, and I won't pretend otherwise. It did, however, give people more function in the life they are living right now.
For a lot of people, that's not a small thing... that's everything 💪