DLG4 Synaptopathy - SHINE Syndrome

Home
United States
Dayton, OH
DLG4 Synaptopathy - SHINE Syndrome

Call Directions Website

Contact information, map and directions, contact form, opening hours, services, ratings, photos, videos and announcements from DLG4 Synaptopathy - SHINE Syndrome, Medical and health, C/O PSM Registered Agent LLC/2775 Orchard Run Road, Dayton, OH.

DLG4 SHINE Foundation supports families, funds PSD-95 research, and raises awareness of SHINE Syndrome—a rare disorder caused by DLG4 gene mutations affecting brain development.
*Managed by the board of the DLG4 SHINE Foundation

11/03/2026

Kudos to the student-lead effort at Swan Valley School District for organizing and facilitating this fundraising event for DLG4 SHINE! What a fun way to raise awareness and resources during their recent home football game.

Thank you to all of the students involved and to the Pavlik Family for sharing your photos with us! 💜🖤💛

11/01/2026

Happy Halloween from our spooky SHIINEing Stars

10/29/2026

Can a single functional gene copy hold the key to a future treatment?

Dr. Jeff Coller is investigating whether boosting expression from the functional copy of the DLG4 gene may offer a new therapeutic pathway for individuals with SHINE Syndrome.

Research like this represents more than scientific discovery. It represents hope for families searching for answers and possibilities for improved outcomes.

Read more about this project at https://www.dlg4shine.org/homepage-announcements/dlg4-shine-foundation-supports-innovative-research-exploring-a-potential-rna-based-approach-to-increase-psd95-expression

10/20/2026

Last year's fundraising support helped our efforts in so many big ways in 2026. We sincerely thank everyone who made a contribution to the foundation last year and we invite you to learn more about the advances made this year because of you!

Read more about each project at https://www.dlg4shine.org/research.

10/07/2026

MARK YOUR CALENDAR: Our annual Town Hall will be held virtually on November 1, 2026 to present the foundation's accomplishments over the past year and goals for the coming year.

We encourage our entire community—parents, grandparents, relatives, caregivers, researchers, clinicians, advocates—to attend to hear about the work we're doing and the community we're building.

Use the link below to attend on NOVEMBER 1!
https://us06web.zoom.us/j/88662871425?pwd=JFkP4BYSAtTJOpXqZNjj4cgaGODpeE.1

09/22/2026

Today's SHINEing Star is sweet, happy Eloise who loves sensory activities on the playground and her twin brother Leone.
Read more about Eloise and her peer at https://www.dlg4shine.org/rare-stars

Image description: A little girl is standing outside on a path and smiling
Text reads: DLG4 SHINEing Star; Favourite foods: Berries, Kiwi, Bananas, Carrots and Bell peppers; Favourite activities: Spending time outdoors at the playground with her family, especially enjoying the swings, slide, and splash pad; Favourite TV Shows: Ms. Rachel and The Wiggles; Favourite people: Her twin brother Leone; Biggest challenges: Global Developmental Delays & Sensory Challenges; Eloise, Age 2, Florida USA

09/07/2026

Today's SHINEing Star Ivy looks as sweet as the berries she loves to eat 🍓
Read about our SHINEing Stars on our website at https://www.dlg4shine.org/rare-stars

Image description: a little girl with pig tails is sitting on a wooden chair outdoors and smiling.
Text reads: DLG4 SHINEing Star; Favourite foods: Berries; Favourite activities: Picture Books and Swimming; Favourite TV Shows: Gabby’s Dollhouse and Bluey; Favourite people: Her mom and big brothers, her cousin Emma and her Papa; Biggest challenges:Gross Motor Skills; Ivy, Age 1, Missouri, USA

08/17/2026

Meet Joelle, today’s DLG4 SHINEing star, who loves reading, art, pasta, and who’s smile is very contagious. Let’s all take a page off her book, grab a shoulder buddy, and enjoy life to its fullest!
You can read more about our SHINEing Stars on our website at https://www.dlg4shine.org/rare-stars

Image description: A teenage girl with a stitch toy on her shoulder is looking and smiling at the camera
Text reads: DLG4 SHINEing Star; Favourite foods: Pasta, Favourite activities: Reading and Art, Favourite TV Shows: K Pop Demon Hunters, Favourite people: Her best friend Emma, Biggest challenges: Meltdowns and Anxiety. Also struggles with remembering things; Joelle, Age 13, California USA

08/13/2026

Exciting progress in rare disease research!

A recently published study has successfully reproduced key symptoms of DLG4 SHINE Syndrome in mice, marking an important milestone in understanding how the disease develops. By creating reliable animal models, researchers can better investigate underlying mechanisms, test potential therapies, and move promising treatments closer to patients.

Scientific breakthroughs often begin with advances like these, laying the groundwork for future innovations that could transform lives.

Thank you to all the co-authors & collaborators who made this work possible. A heartfelt thank you also goes to the wonderful DLG4 SHINE families involved in this study. Your dedication and partnership in advancing DLG4 research truly mean the world to us.

Read the paper at https://www.dlg4shine.org/articles

07/30/2026

We’ve reached a milestone: 300 known cases of DLG4 SHINE Syndrome have now been identified!

Each case represents a person, a family, and a story. Together, we all are helping better understand this disease and move research forward.

This milestone reflects growing awareness, stronger collaboration, and the power of shared experience. It also brings us closer to improved diagnosis, care, research, and potential future treatment options.

Thank you to every family, clinician, and researcher who helps make our progress possible. 💛

Together, we continue to build knowledge, connection, and hope.

If you have not yet, please register on our website at https://www.dlg4shine.org/register to be part of the count!

Address

C/O PSM Registered Agent LLC/2775 Orchard Run Road
Dayton, OH
45449

Telephone

+16132901982

Website

http://dlg4shine.org/

Alerts

Be the first to know and let us send you an email when DLG4 Synaptopathy - SHINE Syndrome posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.