Dr. Adam Mamelak

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☀️ SUNLIGHT IS NOT A RELIABLE VITAMIN D PRESCRIPTION.Vitamin D is essential for bone health, calcium absorption, muscle ...
10/08/2026

☀️ SUNLIGHT IS NOT A RELIABLE VITAMIN D PRESCRIPTION.

Vitamin D is essential for bone health, calcium absorption, muscle function, and immune health. But is spending more time in the sun the best way to get it? Not so fast.

Here’s why using UV exposure to optimize vitamin D is problematic 👇

🧬 DNA DAMAGE: UVB triggers vitamin D production, but it also damages DNA and contributes to skin cancer. UVA accelerates photoaging, wrinkles, and loss of skin elasticity.

🌎 LOCATION MATTERS: During winter, UVB levels may be too low for meaningful vitamin D production in many locations. This seasonal “vitamin D winter” varies with latitude, weather, and other factors.

☁️ SUNLIGHT IS UNPREDICTABLE: Clouds, air pollution, time of day, season, and skin pigmentation all affect how much UVB reaches your skin. There is no universal sunlight dose that reliably produces a specific vitamin D level.

⏳ AGING CHANGES THE EQUATION: Older skin produces less vitamin D in response to UVB than younger skin, making sunlight an even less predictable source.

🪟 BEHIND GLASS? Ordinary window glass blocks most UVB radiation needed for vitamin D synthesis, while allowing some UVA to pass through.

🧴 WHAT ABOUT SUNSCREEN? Proper sunscreen use reduces UVB exposure, but real-world application varies. You should never intentionally skip sunscreen or burn your skin to boost vitamin D.

💊 THE SMARTER STRATEGY: Get vitamin D through foods, fortified products, and supplements when appropriate. A blood test can help determine whether you have a deficiency and need supplementation.

The bottom line: You can’t reliably control your vitamin D level by controlling your sun exposure. But you can reduce UV damage and address vitamin D needs without deliberately exposing your skin to carcinogenic radiation.

Protect your skin. Get your vitamin D intelligently.

Medical studies confirm that one blistering sunburn during childhood or adolescence can nearly DOUBLE your risk of devel...
10/05/2026

Medical studies confirm that one blistering sunburn during childhood or adolescence can nearly DOUBLE your risk of developing melanoma later in life.

And the more burns you experience, the greater the risk. Research has found that 5 or more blistering sunburns between ages 15–20 are associated with an 80% higher risk of melanoma.

Despite this, getting a unburnt is still incredibly common. In 2024, approximately 88 million American adults (35.1%) experienced at least one sunburn. About 19 million had 4 or more sunburns.

UV damage is cumulative. Unfortunately your skin doesn’t simply reset after the redness and peeling disappear.

If you’ve had blistering sunburns as a child, don’t panic. It doesn’t mean you’re destined to develop skin cancer. It means your history is one more reason to be diligent about sun protection and regular skin examinations.

Protect your skin today. Your future skin will thank you.

SUBCISION FOR ACNE SCAR TREATMENT Subcision, short for subcutaneous incisionless surgery, was formally described by derm...
10/01/2026

SUBCISION FOR ACNE SCAR TREATMENT

Subcision, short for subcutaneous incisionless surgery, was formally described by dermatologic surgeons in 1995. The concept was simple but powerful:

Release the scar from below by cutting the fibrous bands pulling the scars downward and allow it to rise, stimulating new connective tissue formation in the process.

Today, physicians use
A variety of tools for subcision, including traditional hypodermic needles, Nokor needles with a cutting tip, Blunt cannulas, specialized blunt blades and wires, as well as energy-assisted devices.

Subcision is particularly effective for rolling acne scars—broad, shallow depressions with smooth edges that appear tethered to deeper tissue.

It is generally much less effective for classic ice-pick scars. Boxcar scars may sometimes benefit, but treatment depends heavily on their depth and whether they are tethered.

Subcision is generally not a one-treatment cure for acne scars. Some patients see improvement after one treatment, while others require multiple sessions or combination therapy with resurfacing and fillers.
The goal is usually improvement, not perfection.

In September 2026, the FDA approved Ameluz® (aminolevulinic acid) + red-light photodynamic therapy (PDT) for the treatme...
09/28/2026

In September 2026, the FDA approved Ameluz® (aminolevulinic acid) + red-light photodynamic therapy (PDT) for the treatment of superficial basal cell carcinoma (sBCC) in adults. Ameluz is now the first FDA-approved photodynamic therapy drug in the U.S. specifically indicated to treat a skin cancer.

Ameluz contains 5-aminolevulinic acid (ALA), a precursor in the heme biosynthesis pathway. When applied to a BCC, tumor cells preferentially accumulate protoporphyrin IX (PpIX). When the treated area is exposed to a specific red light, PpIX becomes activated and generates reactive oxygen species.

The result: selective cellular damage and destruction of the cancer cells.

Until now, Ameluz was FDA-approved for precancerous skin lesions known as actinic keratoses (AKs) of the face and scalp. This new approval represents an expansion from treating precancerous sun-damaged skin to an actual skin cancer.

The FDA approval was supported by a randomized, double-blind Phase 3 trial involving 187 patients with superficial BCC.

At 12 weeks after the final treatment cycle:

• 75.9% had histologic clearance
• 83.4% had clinical clearance
• 66% achieved BOTH clinical + histologic complete response
• Only 5% of patients receiving placebo + light achieved this combined endpoint.

And 88% of patients rated the cosmetic outcome as good or very good.

For appropriately selected superficial BCCs, PDT offers a non surgical approach to cancer treatment. This could be particularly attractive for patients with multiple superficial BCCs, larger treatment fields, or lesions where minimizing scarring is especially important.

While Mohs surgery is still considered the gold standard for treating BCC, PDT adds another consideration to the dermatologist’s skin-cancer treatment toolbox.

In 2025, the FDA approved the first gene therapy for a severe genetic skin disease. ZEVASKYN is an FDA-approved, cell-ba...
09/25/2026

In 2025, the FDA approved the first gene therapy for a severe genetic skin disease.

ZEVASKYN is an FDA-approved, cell-based gene therapy used to treat chronic, painful skin wounds in adult and pediatric patients with a rare genetic disorder called Recessive Dystrophic Epidermolysis Bullosa (RDEB).

People with RDEB cannot produce functional type VII collagen, a vital protein that acts like “glue” to anchor the outer layer of skin (epidermis) to the deeper layer (dermis). Without it, their skin is extremely fragile and blisters or tears at the slightest friction.

ZEVASKYN fixes this underlying genetic defect locally at the wound site, treating the root cause instead of just managing symptoms. It’s one of dermatology’s most significant frontiers, and a sign of where the field is headed: precision medicine, not just topical management.

Science moves fast. I’ll keep breaking down what it means for real patients.

Liquid nitrogen is one of the most recognizable tools in dermatology. But its history goes back more than 120 years.In 1...
09/21/2026

Liquid nitrogen is one of the most recognizable tools in dermatology. But its history goes back more than 120 years.

In 1899, dermatologist Campbell White reported using liquefied air to freeze skin lesions. Other cryogens followed, including liquid oxygen, solid CO₂ (“carbon dioxide snow”), and liquid nitrogen (LN₂).

LN₂ became commercially available after WWII. In 1950, Dr. Ray Allington introduced liquid nitrogen into clinical dermatology, initially applying it with cotton swabs to warts, keratoses and other skin disorders. In the 1960s, dermatologists developed specialized spray systems and probes that could deliver much deeper and more controlled freezing.

The development of modern handheld cryosprays grew from the work of Setrag Zacarian and engineer Michael Bryne in the 1960s, with Brymill subsequently manufacturing handheld cryosurgical equipment. These devices are capable of delivering a precisely directed jet of −196°C nitrogen.

Liquid nitrogen cryotherapy is particularly effective for:

- Actinic keratoses
- Viral warts — including plantar warts
- Seborrheic keratoses
- Molluscum contagiosum
- Skin tags
- Solar lentigines
- Cherry angiomas and selected vascular lesions
- Some hypertrophic scars and keloids

In selected cases, cryosurgery can also treat certain superficial basal cell carcinomas and squamous cell carcinomas.

More than a century after the first experiments with freezing skin, that familiar blast of white v***r from a Cry-Ac remains one of the simplest—and most powerful—tools in the dermatologist’s office.

A fascinating new study may point toward a completely new approach to skin rejuvenation and anti-aging.Researchers used ...
09/18/2026

A fascinating new study may point toward a completely new approach to skin rejuvenation and anti-aging.

Researchers used mRNA technology to deliver genetic instructions that increased collagen production in photoaged skin.

The results? In aged, UV-damaged mice, the treatment produced an astonishing 86.5% reduction in wrinkle area in just 21 days.

But the bigger idea is what this technology represents:

Instead of simply filling wrinkles or temporarily stimulating collagen, what if we could give aging skin new biological instructions to repair itself and behave more like younger skin?

That could open the door to a future of regenerative anti-aging treatments designed to reverse some of the biological changes of aging—not just camouflage them.

We’re not there yet, but the question is becoming increasingly exciting:

Could the future of anti-aging be teaching our skin how to become younger?



(Xue W et al. Int J Pharm. 2026 Aug)

GHK-Cu is a naturally occurring complex of three amino acids—glycine, histidine and lysine—bound to copper. In 1973, a s...
09/14/2026

GHK-Cu is a naturally occurring complex of three amino acids—glycine, histidine and lysine—bound to copper. In 1973, a substance was identified in human plasma that appeared to make aging liver tissue behave more like younger tissue. That substance was eventually identified as GHK, which naturally binds copper.

GHK-Cu appears to function as a signaling molecule involved in tissue repair and remodeling. Laboratory studies suggest it can stimulate collagen and glycosaminoglycan production, influence matrix-remodeling enzymes, and modulate inflammation and oxidative stress.

TOPICAL: GHK-Cu is widely incorporated into commercially available serums, creams and other skincare products marketed for fine lines, wrinkles, elasticity, firmness, photoaging and skin repair. Small human studies have reported improvements in photoaged skin, although the clinical evidence remains much more limited than the laboratory research.

INJECTABLE: GHK-Cu is also being used by some physicians, wellness clinics and consumers as a compounded or investigational injectable peptide, typically promoted for skin rejuvenation, wound healing and “anti-aging.” However, there is currently no FDA-approved injectable GHK-Cu product for skin rejuvenation or anti-aging.

From human plasma to modern skincare—and now the peptide boom. GHK-Cu may be one of the more interesting examples of how a naturally occurring molecule can inspire new approaches to skin repair and rejuvenation.

It sounds bizarre—but coal tar has been used in dermatology for more than 150 years.Born out of the Industrial Revolutio...
09/10/2026

It sounds bizarre—but coal tar has been used in dermatology for more than 150 years.

Born out of the Industrial Revolution, this byproduct of the destructive distillation of coal was noted to keep factory workers skin clear of skin rashes and disease.

In 1861, French dermatologist Alphonse Devergie reported that coal tar applied to severe eczema unexpectedly improved the inflammation and drainage. This helped spark interest in coal tar as a dermatologic treatment.

A later report by Fischel in 1894 is often cited as the first specific publication describing the therapeutic use of crude coal tar in skin disease.

Then came the famous Goeckerman regimen in 1925, combining coal tar with ultraviolet light to treat psoriasis.

Coal tar works by reducing inflammation, itching, and excessive skin-cell growth and has been used for psoriasis, eczema, seborrheic dermatitis, and other scaly inflammatory conditions.

Messy? Yes. Smelly? Absolutely.
But effective? For many patients, remarkably so.

Today, modern topical medications, phototherapy, and biologics have largely replaced coal tar—but this strange black substance remains an important tool in dermatology.

Address

4235 Williams Drive
Georgetown, TX
78628

Opening Hours

Monday 8am - 5pm
Tuesday 8am - 5pm
Wednesday 8am - 5pm
Thursday 8am - 5pm
Friday 8am - 5pm

Telephone

+15122793376

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