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Head & Neck Network is an online and open access platform dedicated to raising awareness and providing reliable, verified information about head and neck cancers.

11/11/2026

ESTHESIONEUROBLASTOMA

Esthesioneuroblastoma, also called olfactory neuroblastoma, is a rare type of cancer that starts in the nasal cavity.

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11/09/2026

Your gums bleed, swell, or just do not heal. Most times it is gum disease. Sometimes it is not.

Gum cancer, also called gingival cancer, is a form of oral squamous cell carcinoma (OSCC), the most common type of cancer inside the mouth. It often starts on the lower back gums and it is easy to miss because it looks like inflammation, a dental abscess, or a stubborn sore.
New research in 2026 is asking clinicians to pay closer attention. In a large analysis, gingival cancer made up almost one in three oral cancers in the group studied, almost two in three cases were already advanced at diagnosis, and 5 year survival was about 50 percent. In a separate review of 419 cases, incidence rose over 10 years, yet only about six in ten cases were first suspected as cancer, often because it was mistaken for reactive or inflammatory gum disease. A 2026 case report adds a warning: gingival cancer can mimic the inflammatory state of the gums and can appear even without classic risk factors.
Research is also looking at the mouth itself. In a 2026 laboratory study, infection with Porphyromonas gingivalis, a bacterium linked to gum disease, increased interleukin 6, a signaling molecule, and promoted growth and spread of oral cancer cells. In parallel, researchers at the tested extracts from a bioengineered bean chewing gum in saliva and oral rinse samples. The extracts cut human papillomavirus (HPV), a virus linked to head and neck cancer, by 93 percent in saliva and by 80 percent in oral rinse samples, and reduced the gum disease bacteria to almost zero while sparing helpful bacteria. This is early laboratory work, not a treatment you can buy, and it still needs clinical trials.

If something on your gums does not heal, ask your dentist for a prompt check and a biopsy if needed. Early checks save time, and time matters here.

11/06/2026

CD8 cytotoxic T cells recognise infected body cells

11/04/2026

What does a neck lump really mean?

Those small lumps in your neck are lymph nodes - your immune filters.
But in head and neck cancer, they are also the first stop for metastasis.

Swollen ≠ always cancer. Most often it’s reactive from infection.
But a firm, painless, persistent lump that doesn’t go away in 2 weeks is the most common FIRST sign of head and neck cancer in adults.

In this carousel we explain:
→ What happens when lymph nodes swell
→ Reactive vs. Malignant nodes: how to tell the difference
→ How they are linked to head & neck tumors
→ Which cancers can present with a neck lump

Save this. The 2-week rule could save a voice, swallowing, and a life.

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11/02/2026

Could a patch replace surgery for early oral cancer?

Exciting early results from the US.
A new treatment called PRV111 is not an infusion or surgery. It is a small nanoengineered patch that delivers chemotherapy directly onto the lesion inside the mouth, limiting exposure to the rest of the body.
In the ongoing Phase 2 trial, in 22 patients with early-stage oral cancer:
• One month after treatment, pathology found no cancer cells in the treated area in 95.5% of patients
• 21 of 22 patients achieved a complete response after just one cycle
• All patients avoided standard-of-care surgery, with mucosa healed without scarring
It is the first non-surgical therapy in development for early-stage oral cancer. Less surgery means less impact on speech and swallowing.

Source: Privo Technologies. Clinical Update from the Ongoing Phase 2 Trial of PRV111. PR Newswire, Oct 5, 2026. prnewswire.com

10/30/2026

Activated T-cell attacks a cancer cell

Watch this Impressive footage as one of our immune system warriors, attacks a target cancer cell!

10/28/2026

FLOOR OF THE MOUTH CANCER

Floor of the mouth cancer is cancer that starts as a growth of cells under the tongue.
Floor of the mouth cancer most often begins in the thin, flat cells that line the inside of the mouth, called squamous cells. When cancer starts in these cells it’s called squamous cell carcinoma.

Do you want to know more?
Read the slides👇and share

10/26/2026

Early detection of relapse could change head and neck cancer follow-up.

After surgery for HPV-related head and neck cancer, the big question is: do I need more treatment?

Researchers at Mass General Brigham developed HPVDeepSeek, an ultrasensitive blood test that detects tiny fragments of HPV tumor DNA after surgery.
In the Clear-HPVca study of 103 patients with HPV-associated head and neck cancer:
• 98.1% had detectable tumor DNA at diagnosis
• After surgery, patients with negative results were 100% disease-free at 2 years vs 60% for positive
• Recurrence was detected ∼7 months earlier than standard methods, up to 17.5 months
Why it matters: moving from general risk factors to biology-driven decisions, so some patients might avoid overtreatment and others get timely treatment.
This was an observational, single-center study. Larger trials are now planned.

Source: Hirayama et al., Sci Transl Med, June 2026.

10/23/2026

CALLIE AND ALL THE DOGS TRAINED TO SNIFF OUT CANCER 🐾

Not just Callie, who I featured in a previous reel, but a whole squad of amazing pups from . They are the first dogs in the world trained to detect colorectal cancer and Pseudomonas from a urine sample.

In the second part of the reel you can see Jasper and Callie finding two samples at lightning speed. The first contains Pseudomonas, the second is urine from a patient with stage I bowel cancer. Like Callie, Jasper loves his “job”, his trainers and his handlers. For him, it is all a wonderful and fun game.

Launched in 2024 with the Open University in the UK, this groundbreaking project enables a non-invasive, rapid and early test. In the case of Pseudomonas, it can detect a bacterium that causes severe infections, especially in immunocompromised patients, including cancer patients. And all of this is possible thanks to the most powerful nose in existence: a dog’s nose.

Please, never abandon or mistreat them. One day they could save your life.

Video credit:

10/21/2026

Head and Neck Cancer: 5 Red Flags You Should Never Ignore

Early check = better outcomes. It can save your voice, swallowing, and life.

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Oral Cancer Institute Oral Cancer Foundation Make Sense Campaign

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