09/02/2026
🌿 MOUNTAIN MEDICINE — EPISODE ONE: YELLOWROOT
There are things you learn from books—and there are things you learn from the people who came before you.
For Happy, yellowroot (Xanthorhiza simplicissima) is one of those things.
She remembers her grandmother using it. Knowledge passed down through experience, observation, family, and generations of people living closely with the land.
And it felt like the perfect place to begin Mountain Medicine—our new series exploring the plants, remedies, and traditions woven into life here in Appalachia, alongside what modern science can tell us about them.
But the story of yellowroot begins long before our own family stories.
Yellowroot has a documented history of use among Indigenous peoples of the Southeast, including Cherokee, Catawba, and Lumbee communities. Later, the plant became woven into broader Appalachian folk traditions.
Traditionally, yellowroot preparations have been recorded for uses ranging from digestive complaints and sore mouths and throats to use as a bitter tonic.
And here's where the old knowledge gets especially interesting.
Yellowroot contains berberine, the alkaloid largely responsible for its striking yellow color, along with other naturally occurring alkaloids, flavonoids, and phenolic compounds. Modern laboratory research has found biological activity—including antimicrobial activity—in yellowroot extracts and compounds isolated from the plant.
Does that mean every traditional use has been scientifically proven? No. Human clinical research specifically on yellowroot is still limited, and traditional use shouldn't automatically be treated as clinical evidence.
But science can help us understand why some of these plants may have been valued for generations.
That's what Mountain Medicine is about.
Not romanticizing every old remedy.
Not dismissing generations of lived knowledge, either.
We're going back to the plants, the people, and the stories—and looking at them again through the lens of modern science.
And we're starting with one Happy remembers from her grandmother. 💛🌿
Welcome to Mountain Medicine.