Dovetail Genomics

11/10/2026

Over 50% of late-stage cancers are still driver negative (Attalla et al., 2021).
That's not a small gap in the catalog — it's a signal that we're missing important biology. A lot of it comes down to two factors:

1. Standard short-read NGS struggles to detect large structural variants (SVs).
2. FFPE samples are the most abundant resource in cancer research, yet nucleic acid degradation makes them challenging for most genomic assays.

Dovetail FFPE Assay changes the math by using linked-read sequencing technology to generate libraries that leverage both breakpoint-spanning and breakpoint-flanking reads thereby expanding the detection window to megabase-scale regions and significantly boosting sensitivity - all on standard short-read sequencers. No specialized equipment required.

The result: a comprehensive single-assay solution for FFPE tumor profiling that fits your existing NGS infrastructure.

Learn More: https://na2.hubs.ly/H08Vpxk0

11/04/2026

Your multi-omics data tells you what changed. It doesn't always tell you how.

RNA-seq, ATAC-seq, ChIP-seq and methylation profiling are powerful, but they cannot reveal everything. They can show you a differentially expressed gene and several candidate enhancers nearby. However, they can't show you which of those enhancers is physically in contact with the gene and therefore is driving gene expression.

That's the gap 3D Genomics fills. By mapping the chromatin architecture that brings regulatory elements and their target genes together, it adds a vital spatial layer to the data you already have.

That's the difference between knowing what changed and understanding how and why it changed.

And it doesn't mean starting over. 3D Genomics complements your existing assays, and the libraries run on standard short-read sequencers.

Read the full post: https://na2.hubs.ly/H08PzPp0

10/29/2026

🐢 At an estimated 194 years old, Jonathan has a remarkable story—and researchers are looking to his DNA for clues to his extraordinary longevity.

A new study in Science Advances explores the genetic and epigenetic features of the world’s oldest known living land animal, identifying differences in pathways involved in DNA repair, mitochondrial function, and other processes associated with aging.

With coverage in Smithsonian Magazine and Live Science, Jonathan’s story is bringing genomic research to a wider audience and sparking curiosity about the biology of aging.

Dovetail Omni-C helped scaffold the reference genome used to analyze Jonathan’s DNA. Researchers assembled that genome from Tank, a younger Aldabra giant tortoise, using PacBio HiFi sequencing and Omni-C scaffolding.

Congratulations to the research team on this fascinating contribution to longevity research!

Read the study: https://na2.hubs.ly/H08zQb90

Aldabra giant tortoises (Aldabrachelys gigantea) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises (A. gigantea and ...

09/18/2026

🧬 A great few days at AEpiA 2026!
Dovetail Genomics was proud to sponsor the Australasian Epigenetics Alliance (AEpiA) Meeting in Adelaide.

It was inspiring to connect with researchers using epigenetics to better understand gene regulation, development, and disease—areas where Hi-C can add an important 3D perspective to multiomics studies.

🔬 We were especially delighted to see poster presentations featuring Dovetail technology and to hear directly from researchers about their findings and how they’re applying 3D genomics in their work.

There was also plenty of interest in Dovetail LinkPrep, our Tn5-based Hi-C solution, particularly its broad, even genome coverage and streamlined one-day workflow from sample to sequencing-ready library.

🤝 And, of course, it was wonderful to reconnect with familiar faces across the 3D genomics community, meet new ones, and exchange ideas about emerging research and future collaborations.

A big thank you to the AEpiA organisers, poster presenters, and everyone who stopped by our booth to share their research and spend some time with us!

💬 Missed Chui-Li Leaw at AEpiA 2026? No worries—drop us a DM and we’ll help arrange a 1:1 with her to hear about your research and explore how Dovetail technologies could help take your 3D genomics project further.

09/10/2026

🌊🌊How can genomics help protect a species at risk of extinction?🌊🌊

A new study in Scientific Data presents the first chromosome-level, haplotype-phased reference genomes for the Critically Endangered school shark (𝘎𝘢𝘭𝘦𝘰𝘳𝘩𝘪𝘯𝘶𝘴 𝘨𝘢𝘭𝘦𝘶𝘴), a species that has experienced global population declines of more than 80%.

Using PacBio HiFi + 𝗗𝗼𝘃𝗲𝘁𝗮𝗶𝗹® 𝗢𝗺𝗻𝗶-𝗖®, researchers generated a chromosome-level reference genome designed to support future studies of genetic diversity, population management, and conservation.

Read the publication here: https://na2.hubs.ly/H07w4pj0

09/08/2026

Don’t take our word for it—hear from our customers!

Want to uncover more from archived FFPE samples?

Researchers at the National Cancer Centre Singapore used the Dovetail® FFPE Assay to characterize structural variants and resolve complex genomic rearrangements in tumor samples—providing insights into molecular features that may help us better understand cancer development.

08/31/2026

What if one of our best tools for preventing extinction is hidden inside the species themselves?

From sharks to butterflies, chromosome-level genomes are giving conservationists a clearer picture of genetic diversity, inbreeding, and population health - while there’s still time to act.

Read the full blog: https://na2.hubs.ly/H07w3-p0

08/27/2026

SV SPOTLIGHT: Structural variants, like other genetic variants, can be either germline or somatic.

Germline variants are inherited, while somatic variants arise during life. Understanding the difference can be critical for assessing disease risk, cancer diagnosis, and treatment decisions.

Learn more about it here: https://na2.hubs.ly/H07qgQq0

08/20/2026

SV SPOTLIGHT: Structural variants can do more than alter DNA, they can rewire gene regulation and help drive cancer.

Learn more about it here: https://na2.hubs.ly/H079XhD0

08/18/2026

Our team had an incredible time at AACR 2026!

Check out our latest blog for highlights from AACR and a look back at our time in San Diego: https://na2.hubs.ly/H079_V30

Discover how AACR 2026 highlighted advances in structural variant detection, ecDNA, linked-read sequencing, FFPE analysis, and 3D genome analysis.