10/05/2026
Could stealth pathogens like Babesia and Bartonella be playing a role in some cases of severe mental illness?
A new case series from our partners at NC State examined postmortem blood, tissue, and other samples from six chronically ill young people who had experienced suicidal ideation or ended their lives.
DNA sequencing confirmed Babesia, Bartonella, or both in five of the six individuals.
And the way those pathogens were found is just as important.
Researchers tested 125 samples using conventional qPCR. Every result came back negative.
It was only when they used more sensitive methods, including digital PCR and enrichment culture, that they were able to find signs of the pathogens and confirm the pathogen presence through DNA sequencing.
And while this study cannot tell us whether Babesia or Bartonella definitively caused their mental health symptoms, it is yet another reason to investigate what may be happening behind psychiatric illness. As cases continue to rise, we cannot treat the brain as if it is separate from the rest of the body.
It also shows why the right diagnostic tools are so critical.
Some pathogens can be difficult to find because they may be present in the bloodstream in extremely small amounts. If the test is not sensitive enough, a stealth pathogen may not be found, leaving patients and practitioners without the information they need to guide support and care.
We are so grateful to these young people and their families, who made this research possible by providing postmortem samples in the hope that others may receive better answers in the future.
If you or someone you know is in crisis, call or text 988 in the United States.
Reference: Breitschwerdt, E.B., Robveille, C., Maggi, R.G. et al. “Postmortem evidence of Babesia and Bartonella infections in chronically ill suicidal young people.” Parasites & Vectors, 19, 376 (2026). https://doi.org/10.1186/s13071-026-07541-8