EpiCypher Inc.

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EpiCypher Inc.

EpiCypher is a bioscience company developing unique reagents and services for chromatin biology and epigenetics research.

A pioneer in the field of epigenetics and chromatin biology, EpiCypher is a bioscience company developing transformative technologies and delivering superior products to researchers world-wide. Our technologies and products are making studies possible that were not imaginable just a few years ago. Our innovation is a direct result of the scientific power associated with EpiCypher. Our renowned chr

omatin researchers possess expertise and unique insight into epigenetics that benefit our customers in ways other companies cannot. Arising from an abundance of demand for high quality products from the laboratories of Mark Bedford, Brian Strahl, and Or Gozani EpiCypher was founded on January 18, 2012 as a spin-out from University of North Carolina at Chapel Hill. Starting with the groundbreaking and proprietary histone peptide array platform, EpiGold™, EpiCypher has developed a wide portfolio of best in class products. EpiCypher's mission is to develop products to enable researchers to complete experiments that are not otherwise possible.

06/05/2026

🧬 Your FFPE archive holds years of biological insight. The challenge? RNA quality often limits what you can learn from archived tissue.

CUTANA™ FFPE Transcriptional Activation Profiling helps researchers uncover transcriptional insights from archival FFPE samples without relying on RNA. Want to know if CUTANA™ FFPE is a good fit for your project?

Register for our June 24 webinar for an exclusive first look at CUTANA™ FFPE.

This webinar will be especially relevant if you are:
✅ Hitting the limits of RNA-seq or ATAC-seq on FFPE material
✅ Searching for oncology biomarkers that RNA-seq can't access
✅ Working with retrospective cohorts or limited archival tissue
✅ Studying disease states, tumor heterogeneity, or primary vs. metastatic tissue

At the end of the webinar, we'll share how to apply for EpiCypher's CUTANA™ FFPE Grant Program. This program is designed to help researchers explore CUTANA™ FFPE in their own work.

Register for the webinar here ⤵️
https://ow.ly/tnqU50Z88ml

06/02/2026

🧬 We are proud to sponsor the Fragile Nucleosome Seminar Series on June 3 at 9:00 AM PDT.

This session will feature talks from three researchers advancing work across chromatin biology, transcriptional regulation, enhancer activity, and chromatin remodeling:

1️⃣Mark Geisler, University of North Carolina
“Cell cycle-regulated transcriptional pausing controls replication-coupled Drosophila histone gene expression”

2️⃣Jake Cornwall-Scoones, UCL & University of Cambridge
“Pairwise rules govern signal-responsive enhancer activity”

3️⃣Siddhant Jain, Dana-Farber Cancer Institute, USA
“Discovery of a SWI/SNF-specific Ig-fold, SWIFT, as a transcription factor binding platform”

Register here: https://ow.ly/KYsm50Z6KVb

06/01/2026

☀️ Summer savings are here! Now through August 31st, save 15% on our CUTANA™ CUT&Tag Kit (either size) with promo code CTK15.

EpiCypher’s CUTANA™ CUT&Tag Assays offer a faster, simpler alternative to ChIP-seq with lower sequencing costs, reduced cell input requirements, and high signal-to-noise performance. Shop now and use code CTK15 at checkout.

*Offer available to U.S. customers and select international distributors - check with your local distributor for promotion availability.

Shop now: https://www.epicypher.com/product/cutana-cuttag-kit/

05/29/2026

📹In this on-demand webinar, Dr. Yael David (Memorial Sloan Kettering Cancer Center) explains how her lab leverages CUTANA™ CUT&Tag to map histone glycation within T cells during activation and further explore how these chemical and metabolic forces reshape chromatin structure and function, revealing new principles of epigenetic regulation across canonical and non-canonical contexts.

Watch Dr. David's full presentation: https://ow.ly/u32O50Z5fvR

05/27/2026

5 days left to save 15%!

For a limited time, U.S. customers can bundle the CUTANA™ CUT&RUN Kit + Library Prep Kit and save 15% through May 31, 2026.

The Perfect Pair gives you a streamlined CUT&RUN-to-library prep workflow built for:

- Reliable performance with low background and high reproducibility
- Compatibility with low cell numbers and precious samples
- A simplified, integrated workflow designed for efficiency
- High-quality libraries optimized for downstream sequencing

Learn more: https://www.epicypher.com/product/perfect-pair-cutrun-kit-library-prep-bundle

05/25/2026

Today, we remember and honor the brave men and women who made the ultimate sacrifice in service to our country.

At EpiCypher, we pause to reflect with gratitude on their courage, dedication, and legacy.

Wishing everyone a safe and meaningful Memorial Day!

05/22/2026

10 DAYS LEFT to Bundle & Save 15% on our CUTANA™ CUT&RUN Kit + Library Prep Kit!

When it comes to high-resolution genomic mapping with low input requirements, CUT&RUN remains a trusted gold standard. To support your research, we are offering a limited-time 15% discount on our popular CUTANA™ CUT&RUN Kit + Library Prep Kit bundle. This special discounted offer is available exclusively to U.S. customers until May 31, 2026.

Together, the Perfect Pair provides:

- Reliable performance with low background and high reproducibility
- Compatibility with low cell numbers and precious samples
- A simplified, integrated workflow designed for efficiency
- High-quality libraries optimized for downstream sequencing

Learn more here: https://www.epicypher.com/product/perfect-pair-cutrun-kit-library-prep-bundle/

05/20/2026

What regulatory features are missed when epigenomic data cannot be mapped with short reads?

A recent neuroscience study from researchers at the Icahn School of Medicine at Mount Sinai used Fiber-seq to profile human brain tissue and identified approximately 20,000 accessible chromatin regions that were missed by short-read epigenomic sequencing approaches.

Our new blog summarizes these findings and highlights how Fiber-seq, a multiomic long-read sequencing assay, helped researchers resolve regulatory information directly on individual chromatin fibers, including:

✅ Cell-specific promoter and enhancer elements
✅ Nucleosome positioning near transcription start sites and regulatory motifs
✅ Regulatory features within sequences that were previously difficult or impossible to map using short-read methods

Read our blog to learn how CUTANA™ Fiber-seq is expanding what researchers can see in the epigenome.

https://ow.ly/R1cM50Z1L5i

05/15/2026

🧬 EpiCypher® is proud to sponsor the Fragile Nucleosome Seminar Series on May 20 at 9 AM PDT.

This session features Maggie H. Chassé from Boston Children’s Hospital and Pengda Liu from the University of North Carolina at Chapel Hill, sharing research on enhancer pre-programming, MAPKi resistance in melanoma, and nuclear cGAS.

Register to join the seminar: https://us06web.zoom.us/webinar/register/WN_i4n53UTdQLO8okWVfykxJQ

05/14/2026

Studying ADP-ribosylation (ADPr) in chromatin? Your substrate matters. 🧬

EpiCypher is proud to introduce the first commercially available, fully defined nucleosomes with ADP-ribosylation marks, built for researchers studying the impacts of ADPr in cancer biology, DNA replication, DNA damage response, and more.

Applications & Impact of EpiCypher’s ADPr Nucleosomes:

✅ Physiological context: Go beyond peptides with a substrate that better reflects the multivalent interactions driving chromatin biology.

✅ Expanded diversity: Access the most comprehensive collection of 100+ designer nucleosomes, now expanded to include ADPr.

✅ Built for discovery: Defined substrates enable mechanistic insights, structural studies, and inhibitor screening workflows that drive basic and translational research.

Explore the new portfolio of ADPr Recombinant Nucleosomes and discover how defined chromatin substrates can help accelerate your research: https://ow.ly/5vEo50YYukj

Address

6 Davis Drive
Durham, NC
27709

Telephone

+18553742461

Website

http://www.epicypher.com/

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