CIRSx

09/11/2026

Chronic Inflammatory Response Syndrome isn’t in your head—it’s a real, multisystem illness triggered by exposure to biotoxins. The CIRS Protocol is the only published, peer-reviewed way to treat this illness.

Biotoxins from mold, actinobacteria, and endotoxins, put your innate immune system on overdrive. When your body can’t clear them, chronic inflammation takes over—affecting everything from your brain to your joints.

A 12-step, evidence-based sequential treatment designed to: 1️⃣ Remove biotoxin exposure, 2️⃣ Eliminate internal reservoirs, 3️⃣ Restore neuroendocrine balance.

Removal from biotoxin exposure is non-negotiable. Advanced environmental testing or inspection and remediation by qualified Indoor Environmental Professional confirms the space is truly safe. This is where healing begins—everything else depends on it.

Bile acid sequestrants (Welchol/cholestyramine) bind negatively-charged biotoxins in your gut and facilitate excretion through the stool.

MARCoNS (multiple antibiotic resistant coagulase negative staphylococcus aureus) colonizes the noses of ~80% of CIRS patients. Targeted nasal spray (after the first two steps are complete) eliminates this persistent pathogen that fuels symptoms.

Remove gliadin antibodies + restore depleted DHEA (a potent anti-inflammatory hormone). Your HPA axis has been suppressed—rebuilding these supports the immune system and stops the cascade of dysfunction.

The protocol targets 6 key inflammatory markers:

ADH/osmolality (hydration)
MMP-9 (barrier breakdown)
VEGF (tissue oxygen)
C3a & C4a (immune activation)
TGFβ-1 (tissue fibrosis)

Each step corrects one—others often self-correct.

VIP is the final piece: a restorative neuropeptide that down-regulates lingering cytokines AND—remarkably—regrowing gray matter volume in CIRS patients. Brain MRIs show measurable improvement. 🧠

Skip steps or do them out of sequence? Treatment can be unsuccessful. The first three steps are the foundation and they must be completed correctly before biomarker correction. This isn’t intuitive medicine; it’s precision medicine.

The CIRS Protocol is detailed, evidence-based, and peer-reviewed—but it requires trained providers. If

09/11/2026

Hitting 40 can feel like a cliff drop. DHEA levels plummet, signaling big hormonal shifts for both men and women.

At CIRSx 2026, Dr. Dorninger ND, LAc spoke on the importance of correcting androgen, and why it matters even more for people with CIRS as we age.

09/02/2026

just checking!

Welchol (brand name for colesevelam) and Cholestyramine (CSM) are bile acid sequestrants that are FDA-approved for lowering cholesterol but used in the Shoemaker protocol to bind biotoxins in the body.

Once CSM/Welchol enters the GI tract, they bind up biotoxin-laden bile and carry those compounds to the toilet.

Comment “protocol” for a link to the full paper detailing the Shoemaker protocol, including Step 2: Cholestyramine/Welchol.

08/27/2026

If you’re new here, hi 👋 We’re CIRSx global, a team of dedicated healthcare professionals, environmental experts, and real people who are passionate about helping to solve and resolve chronic illness. Our mission is to transform how industries approach Chronic Inflammatory Response Syndrome, and other environmentally-related illnesses.

Whether you are someone looking for answers to their symptoms, a building professional who wants to learn more, or know a loved one who is going through something similar, our hope is that we can expand awareness and access to quality resources for people who live with CIRS and conditions like it.

If this speaks to you, then you’re in the right place. Follow along for more education, resources, and to see when we drop registration for our next conference which is being held in April 2027.

08/26/2026

Is it really possible to regrow brains? Science says yes.

At the 2024 CIRSx conference, Dr. Dorninger ND, LAc spoke about a ground-breaking study which showed that neural tissue can regrow when the soil is fertile. Comment “brain” for the link to the full paper.

Be sure to follow our account to see when we announce registration for next year’s conference where you can see more incredible talks like this one.

ChronicIllness

08/19/2026

5 Things That Are Actually Worth the Money: CIRS Edition.

Taking a $15 VCS test and clustered symptom screening on survivingmold.com to screen for CIRS

Seeing a shoemaker-certified provider (check out the map on survivingmold.com)

Taking a CIRSx institute course to learn how to make a difference in the CIRS community. Medically Important Remediation is just one of our many offerings for people in all industries!

Using a dust test to test your home environment for sources of biotoxin like mold, endotoxins, and actinobacteria.

Follow our page to see when we announce for CIRSx 2027! Our annual conference is a chance for patients, building professionals, healthcare providers, and more to get together and share research, ideas, and community; to further the understanding and treatment of chronic inflammatory response syndrome.

07/27/2026

Spray foam: what could go wrong?

Bill Weber shared this important story at this year’s CIRSx Global Conference during his talk with Christine Cimabue. Check out talks from our previous conferences at the link in our bio 🔗

06/30/2026

✨CIRSx 2026 in the books!

It’s always such an honor to be surrounded by so many incredible professionals who have dedicated their lives to advancing this field, and to finally meet so many people I usually only connect with through social media, zooms, and emails.

There’s just something really special about getting to come together in person to learn, grow, collaborate, talk science and research, and share stories of hope and healing.

We work hard all year long. We’re in the trenches daily, educating, advocating, supporting patients, researching, and fighting to move this illness forward. So when we finally get together, it’s not only meaningful, it’s also so much fun to let loose, take a beat, laugh, and just enjoy being with people who truly get it.


Shout out to my co-emcee Dr. Dorninger ND, LAc who still ran most of the show, and Dr. Kellyn Milani - CIRS, Mold, Lyme, Toxins we thank you for taking over to wrap up the conference.

If I didn’t get the chance to meet you this year, I hope we can change that at CIRSx 2027 in San Diego!

04/03/2026

Join us at CIRSx June 2026 in Fort Lauderdale Florida for a powerful 4-day experience focused on cutting-edge research, clinical insight, and real solutions for CIRS and environmental illness

✔️ 16.25 AMA PRA Category 1 Credits
✔️ Leading experts in the field
✔️ Collaboration between clinicians, remediation specialists & patients

This is more than a conference, it’s where the future of care and remediation is being shaped

Early bird pricing available now!!

👉 Register through the link in bio

07/01/2025