09/10/2026
🩸Tiny blood vessels help pancreatic cells get the oxygen and nutrients they need to produce insulin. In diabetes, this blood flow can become impaired, contributing to cell dysfunction.
🔬Using intravital two-photon imaging, Tomohiko Kimura and colleagues from Kawasaki Medical School showed that the diabetes drug liraglutide rapidly improves blood flow around pancreatic islets in diabetic mice through a nitric oxide-dependent mechanism.
Longer-term treatment also reduced low-oxygen conditions in islets and helped preserve insulin-producing cell function. The findings suggest that improving the islet microenvironment may be one way GLP-1 therapies support pancreatic health.
🔗Read the paper: https://doi.org/10.1007/s00125-026-06825-z