10/27/2026
Mayo Clinic is seeking women ages 46-60 with hot flashes and night sweats to participate in a research study. Interested participants should have a body mass index (BMI) above 30 Kg/m² or a BMI above 27 Kg/m² with weight related conditions (for example hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease). The purpose of the research study is to study the effectiveness of tirzepatide, a weight loss medication, to reduce hot flashes and night sweats, and to improve measures of vascular health and aging.
The study consists of 6 visits over 24 weeks. The study includes a medical history and physical exam, questionnaires, urine pregnancy testing, blood draws, body composition studies, non-invasive vascular testing measurement, and participation in a weight loss program. The weight loss program consists of dietary modification and an exercise program. If you agree to participate, you will be assigned by chance to receive tirzepatide or placebo.
For more information, please visit https://mayocl.in/41urItR or contact study team at (904) 953-5290.