10/12/2026
Can scientists predict when proteins in our cells are beginning to move toward disease, and find a way to intervene before irreversible damage occurs?
Georgetown University and the Buck Institute for Research on Aging are co-leading a new research effort to find out.
Supported by a $51.7 million award from the Advanced Research Projects Agency for Health (ARPA-H), the four-year SEEDS consortium brings together researchers from 10 academic institutions and 7 industry partners.
The team will combine laboratory science, computation and artificial intelligence to better understand proteins whose constantly changing shapes have made them especially difficult to predict and target. The research will initially focus on proteins implicated in Alzheimer’s disease and Ewing sarcoma, with the broader goal of learning how to recognize harmful protein changes earlier and potentially redirect them,.
SEEDS is co-led by Georgetown’s Priyanka Joshi, PhD, who is joined by researchers from across the university.
Learn more about the science, the team and the ambitious question they're working to answer: https://medicine.georgetown.edu/news-releases/arpa-h-seeds-announcement/
A research “super team” has received an award of up to $51.7 million from government agency ARPA-H to predict how disease-causing proteins misfold.